Epigenome Technologies Droplet Paired-Tag Kit - 8 Reaction
SKU DP8101
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Epigenome Technologies Droplet Paired-Tag Kit - 8 Reaction
Product Details
Droplet Paired-Tag is an innovative single-cell multiomic assay that simultaneously measures RNA expression and DNA-modifying proteins in the same cell. By tagging histone post-translational modifications (PTMs) - or other proteins such as transcription factors (TFs) - in individual nuclei, the Droplet Paired-Tag Reagent Kit offers a comprehensive snapshot of gene regulation. Designed to integrate with the 10x Chromium® system, this workflow captures both transcriptomic and epigenetic information in a single run, eliminating the need for multiple separate assays.
Key Advantages
- ✅ Comprehensive Epigenetic Profiling: Assess histone states and TF binding, going far beyond open-chromatin or methylation alone.
- ✅ Cell-Specific Insights: RNA-based annotation lets you identify and profile rare cell populations without sorting.
- ✅ Effortless Integration: Seamlessly aligns with leading single-cell barcoding systems (e.g., 10x Genomics ATAC or Multiome kits) for easy adoption.
Application
Ideal for smaller-scale projects or pilot studies, this kit provides the core reagents for eight single-cell chromatin and transcriptomic profiling experiments. Compatible with 10x Genomics ATAC or Multiome systems, it captures up to 80,000 cells total (10,000 cells per reaction), streamlining your workflow without sacrificing data quality.
Performance
- 📈 Throughput & Coverage: Capture thousands of cells in a single run, with high UMI counts for RNA and DNA profiling: 5000+ UMI/cell for broad marks.
- 🧬 Versatility: Compatible with fresh, frozen, and cryopreserved samples, supporting histone PTMs, chromatin remodelers, and transcription factors
- 🔍Robustness: Bulk and single-cell profiling correlations demonstrate high reproducibility, ensuring confidence in results.
What You Need to Get Started
- Antibody: Validated primary antibody for target of interest
- Single-Cell Platform: 10x Genomics Chromium
- Reagents: 10x Genomics Multiome Kit
- Sequencing: Illumina-compatible sequencing system
Company Profile
Epigenome Technologies emerged in 2022 as a spin-out from the pioneering Bing Ren lab at UC San Diego. Recognizing the transformative power of single-cell epigenetic profiling, our founders—Professor Bing Ren (UCSD epigenetics expert and former Harvard postdoc) and Pei Lin (with leadership experience at Illumina and the Salk Institute)—joined forces to brin g cutting-edge single-cell and spatial DNA-binding solutions to the broader research community.
Milestones & Achievements
- $6M in SBIR Grants: Sustaining robust R&D to enhance and expand our epigenetic toolkits.
- BRAIN Initiative: Our flagship technology, Paired-Tag, is actively utilized as part of this prestigious research program.
- High-Profile Publications: Our techniques feature in leading journals, including Nature Methods and Nature Communications, showcasing breakthroughs in single-cell epigenomics and metabolic stress response.
Technology & Differentiation
- First-Mover Advantage: We are among the very first to offer single-cell epigenetic profiling at scale, coupled with a unique multi-omic spatial solution.
- Broad Platform Compatibility: Seamless integration with numerous single-cell systems grants researchers the flexibility to choose a workflow that aligns with their lab infrastructure.
- Impact on Research & Medicine: By mapping regulatory mechanisms that underlie aberrant gene expression, we open new avenues for identifying therapeutic targets and delivering actionable clinical insights.
Our comprehensive approach to gene regulation sets us apart in a competitive biotech landscape. We’ve already proven that single-cell and spatial epigenetic profiling can unlock novel diagnostic markers and inform targeted therapies for conditions previously deemed intractable. As we continue to scale, we welcome conversations with potential acquirers and strategic partners who share our vision for revolutionizing the future of genomic research.
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