Epigenome Multiplex Droplet Paired-tag™ Kit—Optimized for 10x Genomics Multiome
SKU MDP8101
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Epigenome Multiplex Droplet Paired-tag™ Kit—Optimized for 10x Genomics Multiome
Product Details
The Multiplex Droplet Paired-tag™ Kit enables high-throughput, dual-omic profiling of chromatin state and gene expression from the same single cell—now with built-in sample multiplexing to reduce sequencing costs. Compatible with the 10x Genomics Multiome platform, this kit allows researchers to profile multiple samples in a single lane without sacrificing sensitivity or resolution.
Epigenome Technologies, Inc. is a biotech company focused on developing next-generation single-cell multiomic tools for high-resolution analysis of epigenetic regulation and gene expression. Originating from the lab of epigenomics pioneer Dr. Bing Ren, the company uses proprietary technology to decode gene regulation with single-cell precision. Its products and services include kits for simultaneous single-cell CUT&Tag and RNA sequencing from the same cell.
Key Advantages
1. Dual-omic Detection
Simultaneous profiling of histone modifications or transcription factor binding and RNA expression from the same cell.
2. Multiplexing Capability
Pool multiple samples into a single 10x Multiome lane—cutting costs while maintaining data quality.
3. Optimized for Droplet Systems
Seamlessly integrates with 10x Genomics workflows for scalable, high-throughput analysis.
4. Low Input, High Sensitivity
Detect subtle regulatory changes from as few as 50,000 cells per sample.
5. Flexible and Scalable
Compatible with various histone marks, TFs, and sample types—from primary tissues to cultured cells.
Application
- Cost-Efficient Complex Disease Modeling
Study cancer, neurodegeneration, or autoimmune disorders across multiple conditions or time points in one run. - Drug Discovery & Toxicity Screening
Assess regulatory response and gene expression changes across treated vs. control samples in parallel. - Rare Cell Population Analysis
Reveal regulatory dynamics in rare or mixed cell populations without needing cell sorting. - Biomarker Discovery
Identify multiomic signatures linked to disease states, therapy response, or resistance.
Performance
- 📊 Throughput & Coverage: Multiplex Paired-Tag captures thousands of cells per run with high UMI counts. Tissue data from human brain and PBMC show robust DNA and RNA readouts, with broad histone marks reaching 5000+ UMIs per cell.
- 🧪 Versatility: Compatible with fresh, frozen, and cryopreserved samples, supporting histone PTMs, chromatin remodelers, and transcription factors.
- 🎯Robustness: Strong correlation between bulk and single-cell profiling ensures high reproducibility and confidence in results.
What You Need to Get Started
- Antibody: Validated primary antibody for target of interest
- Single-Cell Platform: 10x Genomics Chromium
- Reagents: 10x Genomics Multiome Kit
- Sequencing: Illumina-compatible sequencing system
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